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2) A scheduled job J i links to another scheduled job J j if there exists a scheduled task T of J i which is scheduled within the processing interval of J j.
Let N be the number of nodes (in our case, genes) in the directed graph, and A be the adjacency matrix representation of the graph, a 0-1 matrif (if node i links to j, then A ij =1).
In this case, symmetry is broken, as (c^{i}_{j} neq c^{j}_{i}): even if i links to j, it is possible that j does not link back.
When it comes to clinical neurological manifestation, a β2GP I links to ischemia events [ 15, 16] and also a few case reports associated anti-phospholipid antibodies (including a β2GP I, aCL-IgM, and aCL-IgG) with autoimmune optic neuropathy [ 17] and cerebellar ataxia [ 18– 218.
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To illustrate this point, consider three agents ((i), (j) and (k)) arranged in a line, ((i) linked to (j), (j) linked to (i) and (k), and (k) linked to (j)).
Is linked to Mr. Obama by: Slim ties.
Is linked to Mr. Obama: In too many ways to count.
Is linked to Mr. Obama by: Politics, what else?
Is linked to Mr. Obama by: The briefing book.
Is linked to Mr. Obama by: Mr. Biden.
Is linked to Mr. Obama by: His transition team.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com