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A number of accounts have been advanced, the most important of them being: (i) integrity as the integration of self; (ii) integrity as maintenance of identity; (iii) integrity as standing for something; (iv) integrity as moral purpose; and (v) integrity as a virtue.
Accordingly, treatment of Aif-depleted human cells (Hep3B and HeLa cell lines) with antioxidants (N-acetyl-cysteine or MitoQ) failed to restore complex I integrity [29], suggesting primary loss of complex I, which might increase superoxide leakage.
Third, we showed that siRNA-mediated knock-down of NDUFC2 affected complex I integrity.
Here, we tested our hypothesis by assessing the effect of NDUFC2 silencing in human cells on mitochondrial function, cell life, and complex I integrity.
Nevertheless, it remains unclear whether this interaction is important for the stability and activity of complex I. Here, we show that siRNA silencing of NDUFC2 reduced growth of human D-407 retinal pigment epithelial cells, significantly diminished mitochondrial membrane potential, and interfered with complex I integrity.
Because "swapping" of this amino acid alone led to an altered ability of human NDUFC2 to interact with its mtDNA-encoded binding partner (ND4), it is likely that in order to maintain complex I integrity during evolution, additional compensatory changes must have occurred and were selected for.
Similar(52)
Is integrity in one area of life likely to flow over into others?
Is integrity a zero-sum game, so that for example, the more artistic integrity a person has, the less she has in personal life?
Is Integrity still going?
If I had integrity, I'd return that diploma and promise to do over the coursework from my first couple of years on campus.
But I expect…no I DEMAND integrity in the relationship.
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