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In addition and in a specific way for each electrolyte, the additive (i) inhibits the different steps of charge transfer leading to the zinc deposit and (ii) modifies the kinetic parameters of the slow reactions involved in the formation and destruction of the active sites for zinc deposition.
The skip feature model interactions occurring much later in the pathway, for example, a gene g i inhibits a gene g j to start a process, and later g i regulates another gene g k towards the end of the process.
In arthritis, for example, IFN-γ: (i) inhibits neutrophil trafficking [ 7], (ii) promotes regulatory T-cell function [ 42], (iii) suppresses Th17 cell expansion [ 43], thereby attenuating inflammation and preventing T-cell driven osteoclast activation and bone erosion [ 44] and (iv) limits the biological activity of interleukin-18 [ 45].
However, we found that Skn7 plays new roles in other cellular processes at low PKA activity: i) inhibits growth at 25 °C, ii) It is required for H2O2 resistance, iii) causes growth arrest in glucose at 36 °C, iv) causes growth arrest in acetate at 25 °C, v) causes growth arrest in galactose at 25 °C.
In conclusion, this study demonstrated that PC in TNBC cells (i) inhibits the proliferation (ii) promotes change in the Bcl-2/Bax ratio (iii) inhibits metastasis via actin cytoskeleton disruption (iv) suppresses angiogenesis and (v) down-regulates MAPK signaling pathways to elicit cell death (Fig. 8).
We show that cucurbitacin I inhibits the migration of MDCK cells and B16-F1 melanomalanoma cells, although it has no effect on Dictyostelium discoideum cells.
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Laboratory studies revealed that M-I inhibits the kinase activities of HER2, EGFR, and HER4 with 50% inhibition concentrations of 98, 29 and 280 nmol l 1, respectively (data on file, Takeda Pharmaceutical Company Limited).
Since insulin-like growth factor-I (IGF-I) inhibits caspase activation, it is possible that IGF-I reduces gastric mucosal injury by inhibiting neutrophil activation.
Ubiquitination of RIP1 by c-IAP proteins within TNFR1-associated complex-I inhibits RIP1 dissociation from complex-I.
P-I inhibits the production of prostaglandin E2 in NIH3T3 cells, a mouse embryonic fibroblast cell line [ 2].
The findings that L75P-ApoA-I inhibits stress-induced relocalization suggest that amyloidogenic ApoA-I may affect stress response of the cells.
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