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Most compounds showed better topoisomerase II inhibitory activity compared to topoisomerase I inhibitory activity.
All the compounds, except 39, did not show topo I inhibitory activity.
In contrast, several 3,4-diarylisoquinolinamines showed superior topo I inhibitory activity.
3-Heteroarylisoquinolinamines with greater topo I inhibitory effect exhibited potent cytotoxicity.
Conversely compounds 5e, 5f, 5g and 8a showed weaker topoisomerase I inhibitory activity compared to positive control at 100 μM.
We suggest that piceatannol is a possible lead compound for the development of novel GLO I inhibitory anticancer drugs.
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The highest ACE-I inhibitory activity was observed in plain and herb-enriched cheddar cheese as well as cranberry-enriched cheese.
All the cheese samples had very high anti-ACE-I inhibitory activity, indicating no correlation to phenolic content and activity was even high in 10× diluted samples.
The cheese samples were assayed for total phenolic content, related antioxidant activity, and inhibition of α-glucosidase, pancreatic α-amylase inhibitory activity, and the angiotensin-converting enzyme (ACE -I inhibitory ACE -Ity.
ACE-I inhibitory activity was quantified by a regression analysis of ACE-I inhibitory activity versus peptide concentration.
This range was fractionated into three fractions and ACE-I inhibitory activity determined for each.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com