Sentence examples for I impairments from inspiring English sources

This indicates that: (i) impairments in inhibitory transmission are more important in shaping network excitability than primary changes in excitatory transmission and (ii) network dynamics and excitability are highly dependent on STP dynamics of excitatory and inhibitory synapses rather than on their basal transmission properties.

Our studies indicate that celastrol promotes proteotoxic stress, supported by two feedback mechanisms: (i) impairment of protein quality control as revealed by accumulation of polyubiquitinated aggregates and the canonical autophagy substrate, p62, and (ii) the induction of heat-shock proteins, HSP72 and HSP90.

Is impairment in personality functioning present or not? 2. If so, rate the level of impairment in self and interpersonal functioning on the "Levels of Personality Functioning Scale".

Thus, these animals cannot survive alone at this degree of complex I impairment without intact complex II respiration.

Complex I impairment leads to an increase in the generation of reactive oxygen species (oxidative stress) [6] [8], consistent with reports of elevated markers of oxidative damage to lipids, proteins, and DNA in the SN in PD [9].

The mechanisms underlying dopamine neuron degeneration in PD are incompletely understood, although systemic mitochondrial complex I impairment is a relatively common feature [1], suggesting that mitochondrial dysfunction plays a major role in PD pathogenesis.

However, neither this hypothesis nor the complex I impairment theory can explain how these mutational changes could possibly provide a survival advantage for the RA synoviocytes.

In idiopathic PD, mitochondrial complex I impairment leading to free radical generation which evokes respiratory chain deficits is very well documented [ 6].

The accumulation of α-synuclein within mitochondria leads to complex I impairment, decreased mitochondrial membrane potential (Δ Ψm) and increased reactive oxygen species (ROS) production.

The accumulation of alpha-synuclein within mitochondria has been shown to lead to complex I impairment, decreased ΔΨm and increased ROS production (Devi et al., 2008; Parihar et al., 2008, 2009).

Elevated circulating levels of fetuin-A negatively affect whole-body insulin sensitivity (i) by impairment of insulin signaling in muscle and liver [3] [7] and (ii) by triggering inflammation in adipose tissue and suppression of adiponectin production.