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The production, updating the action to World War I, has lost some of its starch over the years, so that some of the coups de théâtre -- like Parpignol's revealing a death's-head to the audience -- begin to smack of going through the motions.
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Our results showed that, in stark contrast to MB49, MB49-I has lost the Y chromosome and fails to induce any proliferation of anti-H-Y T lymphocytes.
Altogether these data demonstrate that MB49-I has lost expression of antigens present on the Y chromosome, and thus does not activate adaptive immune responses elicited to the male antigen in female hosts.
Herein, using the murine bladder tumour cell line MB49 and its more aggressive variant MB49-I, we demonstrate that the adaptive immune system efficiently limits progression of MB49, whereas MB49-I has lost tumour antigens and is insensitive to adaptive immune responses.
I've lost something.
"I have lost something.
I've lost them.
I've lost elections.
I've lost count.
"I've lost everything".
"I've lost my son.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com