"I guess is" is not a correct phrase in written English, and it is not a commonly used phrase either.
If you want to express the idea of "I guess," the appropriate phrase would be "I suppose" or "I imagine." For example: "I suppose the weather will be nice tomorrow." "I imagine this project will take a few weeks."
Exact(60)
This, I guess, is natural.
Which, I guess, is us?
And that, I guess, is growing up.
"Which I guess is rich in itself.
NOfffurther.
Which I guess is our job too.
"The timing I guess is good.
But that, I guess, is the point.
This, I guess, is supposed to represent progress.
Which I guess is like our own branding.
"The Vatican, I guess, is next," he said.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com