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Thus the identification of SDH-deficient GIST, also referred to as "type 2", helps distinguish between KIT/ PDGFRA mutant, or type I GIST, and a majority of wild type GIST.
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Genes differentially expressed at the mRNA level in I-GIST.
Genes differentially expressed at the protein level in I-GIST.
39 Therefore, downregulation of PML might contribute to the malignant behavior of I-GIST.
34 In addition, PML is located on chromosome 15q, which is frequently lost in I-GIST, 17 suggesting that the decreased level of PML might reflect genomic alteration in I-GIST.
CD34 protein and mRNA had been previously reported to be downregulated in I-GIST, 10, 15 and our present study identified CD34 as a commonly downregulated gene in I-GIST (Table 2).
GIST of the small intestine (I-GIST) show more aggressive behavior than those of the stomach (S-GIST), and the molecular background of the malignancy in I-GIST may include potential prognostic biomarkers.
We identified PML as a commonly downregulated gene in I-GIST at both the protein and mRNA levels.
We identified 18 genes whose expressions differed between S-GIST and I-GIST at both the protein and mRNA levels.
For proteins showing differential expressions, global mRNA expression was compared between 9 I-GIST and 23 S-GIST.
Heat-map of the 132 genes (223 probes) showing differences in mRNA expression between S-GIST and I-GIST.
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