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i Expression levels of the indicated genes in KYJ and smg11 panicles.
Lactate elevated MHC class I expression in monocytes.
MHC class I expression was measured using mAb ILA88.
Topoisomerase I expression was downregulated following 12 hours of exposure to treatment, and topoisomerase I expression recovered 8 hours after SN-38 was removed.
Together these data show that BNP antibody-mediated complement dependent lysis strongly correlates with MHC I expression and that cells with high MHC I expression are killed predominantly.
PRMT1 over-expression rescued lactate mediated increase in MHC I expression.
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TRAMP-C2 cells secrete TGF-β and show low MHC-I expression.
The pituitary reduced IGF-I expression post-pubertally whereas the uterus increased expression.
However, the effect of β3-AR on apoA-I expression in vitro is unknown.
Given that pronounced effects of MEKi were seen on MHC-I expression (Fig. 2a, b), we next explored the effects of MEKi-induced MHC-I expression on tumor cells and subsequent T-cell responses.
This was paralleled by hepatic IGF-I expression (p < 0.01).
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