One patient experienced syncope before anaesthesia during intravenous line insertion.
In the CO group, on arrival at the ED, four (57.1%) experienced syncope, one (14.3%) had a seizure, two (28.6%) presented with chest pain/EKG changes, and one (14.3%) presented with nausea and vomiting.
A fourth patient experienced syncope while on the higher dapoxetine dose.
He was a 2-year-old boy who experienced syncope followed by cardiac arrest after a shock while playing with his 7-year-old brother.
One patient (10%) in the riociguat 2 mg group experienced syncope 6 days after study drug; the AE was reported during the 30-day follow-up period and was associated with additional intake of sildenafil.
Patients also underwent active questioning to determine whether they experienced syncope, or feeling faint, lightheadedness, dizziness or paraesthesia before study treatment started and after removing the impedance pH catheter.
More than one third of the patients in the validation study had been near syncope and more than every 10th patient had experienced syncope in connection with arrhythmia, and it would have been valuable to further explore how often the patients had suffered from these disabling symptoms, but this information is unfortunately not available.
In the study reported by Buvat et al, one patient experienced ventricular tachycardia and another patient had a transient ischemic attack (both receiving dapoxetine 30 mg), and a third patient experienced syncope followed by sinus bradycardia and sinus arrest (after receiving dapoxetine 60 mg).
Patients with stenotic (narrowed) aortic or mitral valves may experience syncope during exercise; these patients are at high risk for sudden cardiac death.
5 In our study, although not statistically significant, the very elderly were more likely to experience syncope.
Cardiovascular deconditioning is thought to induce OI after return from space missions, and crew members can experience syncope in a standing position.
