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Science traditionally aims at avoiding type I errors.
With corrections for baseline trend, fewer Type I errors were made.
Simulation studies show that empirical powers and type I errors are close to their nominal levels.
The main idea is to control for the marginal type I errors of response rate and toxicity rate separately.
Without statistical adjustments to correct for baseline trend, Type I errors greatly increased as baseline trend increased.
A risk of 5% for type I errors and 20% for type II errors was accepted.
The merit of the three methods is explored by calculation and comparison of power and of type I errors.
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These errors are called Type-I errors.
Ignoring this property and assuming independent stages leads into large Type-I errors.
An important issue here is the control of type-I errors (false positives).
Why are these type-II errors more affected than type-I errors?
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com