Sentence examples for I dysfunctions from inspiring English sources

Thus, even for mutations around the flavin site, the increased reactive oxygen species production that is a common feature of complex I dysfunctions (6, 43) is not (generally) a primary effect of the molecular defect, but a secondary effect mediated by the increased NADH levels that arise from inhibition of catalysis (16, 44).

In incidental Lewy body disease, which may be considered as a pre-symptomatic form of PD [ 16] and is present in up to 10% of individuals over the age of 60, GSH depletion is already present in the substantia nigra [ 18], and thus appears to precede complex I dysfunctions, iron accumulation and striatal dopamine loss [ 38].

Several possible non-mutually exclusive causes could be responsible for this: i) dysfunctioning descending aminergic, especially dopaminergic, control [164, 165], ii) malfunctioning hypothalamo-trigeminal control [166], and iii) altered descending opiatergic pain control system [153, 154].

It is mainly a consequence of systemic low-grade inflammation and apoA-I dysfunction.

It is mainly a consequence of systemic low-grade inflammation and apo A-I dysfunction.

Complex I dysfunction is a common, heterogeneous cause of human mitochondrial disease having poorly understood pathogenesis.

Translational analysis of complex I dysfunction facilitates mechanistic understanding of individual gene contribution to mitochondrial disease.

It has been shown that complex I dysfunction is related to the cell apoptosis driven by mitochondria.

This has a direct translational correlate, as some children with mitochondrial complex I dysfunction display hypersensitivity to volatile anesthetics [24].

These observations clearly point to the role of oxidative stress as a causative factor in complex I dysfunction.

The degree of complex I dysfunction does not strictly correlate with extent of gene knockdown (Figure S1) or subcomplex localization (Figure 2a).