Exact(31)
Complex I dysfunction is a common, heterogeneous cause of human mitochondrial disease having poorly understood pathogenesis.
It has been shown that complex I dysfunction is related to the cell apoptosis driven by mitochondria.
These observations clearly point to the role of oxidative stress as a causative factor in complex I dysfunction.
The degree of complex I dysfunction does not strictly correlate with extent of gene knockdown (Figure S1) or subcomplex localization (Figure 2a).
Complex I dysfunction also impairs the oxidation of NADH, which can lead to the production of superoxide radicals through the FMN group of complex I and α-ketoglutarate dehydrogenase [32].
Indeed, the extent of volatile anesthetic hypersensitivity directly correlates with the degree of complex I dysfunction in C. elegans, rather than with dysfunction of any other respiratory chain complex [13].
Similar(29)
Several possible non-mutually exclusive causes could be responsible for this: i) dysfunctioning descending aminergic, especially dopaminergic, control [164, 165], ii) malfunctioning hypothalamo-trigeminal control [166], and iii) altered descending opiatergic pain control system [153, 154].
It is mainly a consequence of systemic low-grade inflammation and apoA-I dysfunction.
It is mainly a consequence of systemic low-grade inflammation and apo A-I dysfunction.
"Then they have to say, 'Well, I guess I've got thinning vaginal walls, I guess I've got a sexual dysfunction, I guess I need estrogen cream, and boy, now I really miss my H.R.T".
Is was thus expected that i) executive dysfunction would be associated with more distress and less perceived control, and ii) that executive dysfunction would be associated with less functional coping (more symptomatic and less non-symptomatic coping).
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