Sentence examples for I compounds from inspiring English sources

Three regions of higher similarity are clearly distinguishable: i) compounds with IDs between 1 and 30 are all PCBs; ii) compounds with IDs between 31 and 55 are PHDDs and iii) the remaining 39 compounds are PCDFs.

Chemical hits were determined using median absolute deviation (MAD) or P-value statistics, i.e. (i) compounds with a residual larger than 2*MAD ('2MAD'), (ii) P < 0.01, (iii) P < 0.05, were defined as hits.

Based on cell toxicity studies (for bioactivity of ACVL2a and ACVL2b, see ESI Fig. 2 †) three groups of important chemical tool compounds were discovered: (i) compounds that contain the privileged 4-bromo-isoxazole motif but do not exhibit any bioactivity (ACVL1, ACVL2a, ACVL2b), (ii) ACV1 with moderate activity and (iii) ACV2 with comparable activity to ACV.

Gold(I) compounds are among the most potent known inhibitors of thioredoxin reductase, attributable to binding of Au(I) to the redox-active selenocysteine residue.

The multichannel blocking profile of class I compounds includes reduction of cardiac potassium currents in addition to their primary mechanism of action, sodium channel inhibition.

Hg3X2Y2 (X = S, Se, Te; Y = F, Cl, Br, I) compounds, their synthesis and polymorphism are investigated in Refs. [1 10].

The synthesis and characterization of Ru II) and Ru II)–Ag(I) compounds are described, in view of their potential use in on/off switchable metal ridge metal nanodevices.

In addition, N-Br and N-I compounds induced Akt inactivation and expression of pro-apoptotic BH3 protein BIM.

The author concluded that BCS class-II compounds will behave as class-I compounds when administered in optimized SMEDDS formulation.

Both N-Br and N-I compounds induced several effects on melanoma cells, related to apoptosis, such as rounding-up, reduction of cellular and nuclear volume, chromatin condensation and DNA fragmentation, and phosphatidylserine outer membrane expression [ 22, 23].

While the application of IVIVC to class-III drugs is limited due to their poor permeability, the solubility/dissolution properties of poorly water-soluble class-II compounds can be greatly enhanced by formulation approaches such as solid dispersion and lipid formulations such as SEDDS and SMEDDS, thereby making them behave as class-I compounds in vivo.