Sentence examples for I blocking from inspiring English sources
Among the suggested mechanisms by which amiloride alleviates lithium-induced urinary concentrating defect are as follows: i) blocking of epithelial sodium channel ENaC, resulting in reduced absorption of lithium into collecting duct cells (Walker et al. 1982), and ii) restoring to normal the expression levels of AQP2 and AQP3 (Bedford et al. 2008).
After having tested various combinations of antisense sequences, we were surprised to realize that the dogmas: i) blocking endogenous splicing signals on the nascent pre-mRNA transcript via base-pairing or ii) on the contrary, bringing the replacing exon closer to endogenous splice site to be joined, did not produce the best results.
Thus, targeting p75NTR could protect neurons from Aβ by at least three possible mechanisms: i) blocking a deleterious interaction between Aβ and p75NTR; ii) down-regulating deleterious signaling (calpain, GSK3β and c-Jun) which mediates Aβ toxicity; iii) upregulating survival signaling (AKT) which is normally inhibited by Aβ and which can antagonize Aβ mechanisms.
Together these data reveal that (i) blocking Neogenin association with lipid rafts prevents neuronal damages following ischemia and that (ii) this treatment can be delayed and still results in significant functional benefits.
In general, P-gp can be inhibited via (i) blocking the drug binding site competitively/noncompetitively/allosterically, (ii) by interfering with ATP hydrolysis, and (iii) by altering the integrity of the cell membrane lipids [ 45].
We calculated minimal intervention sets of targets, whose inhibition might sensitize tumours by fulfilling three intervention goals: (i) blocking cell cycle arrest, (ii) blocking activation of anti-apoptotic NF-κB, and (iii) keeping at least one pathway activating 'onset of apoptosis' intact.
