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The two usually considered distinct subtypes of Hunter syndrome are (i) attenuated (or mild) and (ii) severe.
Furthermore, under Ni exposure conditions (1 mM for 4 h), the transfection of the miR-210 inhibitor (I) attenuated the Ni-induced ISCU1/2 downregulation compared with that of the inhibitor-control (IC, Figure 2f).
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This article focuses on the rational design of strategies to modulate appropriate immunological effector functions on the basis of selection of (i) attenuating mutations of the Salmonella strains, (ii) specific expression systems for the heterologous antigens, and (iii) route of mucosal administration.
At the dose of.1 μg, IGF-I attenuated these signs of sickness in TNFα but not in IL-1β-treated mice.
At the dose of 1 μg, IGF-I attenuated IL-1β-induced immobility and the reduction in social exploration but had no effect on loss of body weight.
St Louis, D. et al. Invariant NKT Cell Activation Induces Late Preterm Birth That Is Attenuated by Rosiglitazone.
NGF, but not IGF-I, attenuated the MMP decrease elicited by high glucose concentrations.
In contrast, IGF-I rescued MCF7 cells from paclitaxel-induced apoptosis, which required both PI-3K and MAPK, suggesting that the drug mechanism-specific action in IGF-I attenuated the response of breast cancer cells to doxorubicin and paclitaxel (Gooch et al, 1999).
Central administration of insulin-like growth factor-I (IGF-I) attenuates sickness behavior in response to the cytokine inducer lipopolysaccharide.
The mechanism by which IGF-I attenuates the increase in proteasome expression induced by Ang II has not been evaluated, but IGF-I has been previously shown to suppress increases in C-2, -3 and -8 proteasome subunit mRNAs in the skeletal muscle of rats treated with dexamethasone as well as mRNAs for ubiquitin and E2 (Chrysis et al, 2002).
And now I can turn the low frequency gain down so that I attenuate the low frequencies by much as 12 dB.
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