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(i) A good filtration on a small category I is a collection of full subcategories (I_{le n} subset I), one for any non-negative integer n, such that (I_{le n} subset I_{le n+1}) and (I = bigcup I_{le n}).
In support of this idea, (i) a good alignment is observed between the PrP GPI anchor signal sequence and the ZIP10 TM1 domain for both fish and mammals (Figure 3A), and (ii) a consistent distance can be observed between the CFC domains and membrane attachment sites in the two protein families.
Based on two rather reasonable assertions (i) a good modelling strategy should consider all available variables as potential effects in the model, and (ii) gene expressions are highly interconnected, we suggest that an eQTL model for a given gene should consider the rest of expression levels as potential regressors as well as the markers to identify regulatory polymorphisms.
Based on two reasonable assertions (i) a good model should consider all available variables as potential effects, and (ii) gene expressions are highly interconnected, we suggest that an eQTL model should consider the rest of expression levels as potential regressors, in addition to the markers.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com