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Also, in phase 1 clinical trials, women have been given as high a dose as 800 mg I3C per day with high tolerability [ 43– 45], suggesting that relatively high doses of I3C can be tolerated without any adverse side effects.
Furthermore, flexible test demonstrate the graphene paper based sensing device has high tolerability to mechanical stress.
All catalysts tested exhibited high tolerability towards –CH=N– group (confirmed also by the in situ 1H NMR study) providing polyacetylenes with aromatic Schiff base type pendant groups.
Preliminary in vivo results indicated a strong antitumor activity on human mesothelioma primary cell line MM473 orthotopically xenografted in CD-1 nude mice and very high tolerability.
In addition, the Pt-NCs@PEI have large Stocks-shift (∼150 nm), high tolerability to the extreme pH and high ionic strengths, and excellent photo-stability under UV vis irradiation, lay the foundation for the practical bio-applications.
This phase I pilot study demonstrates that choline supplementation at 500 mg/d for 9 months in children aged 2 to 5 years is feasible and has high tolerability.
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The combination therapy did not reduce patient tolerance of the medications, and the combination regimen had higher tolerability ratings than tretinoin gel.
New intranasal catheters that claim to offer higher tolerability have been developed [2].
Other antiepileptics with lesser evidence of efficacy, but a higher tolerability profile can be alternatively used, such as gabapentin and, in some cases, pregabalin [401].
Available evidence about safety profile of LC [9,23] suggested an equivalent or higher tolerability than CB, so the results shown could be considered underestimating the total cost of CB.
This observation also indicates that the insensitivity of mammalian cells to the action of artemisinins does not arise from higher tolerability towards ROS, but inability to interact with artemisinins to generate significant amount of free radicals.
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