Indication of cases with medullary carcinoma for BRCA1 testing, regardless of the family history, may be helpful in mutation screening.
The 2 Mb region of the BTA15 chromosome is involved in genetic background of posthitis and should be closer examined to find causal mutations helpful in better understanding of the disease ethology and to control its incidence in the future.
This subregion should be closer examined to find causal mutations helpful in better understanding of the genetic background of the disease and to control its incidence in the future.
Previously we found it helpful to plot mutation bias versus minimal contrast for 2 4 bp contexts to identify mutation regularities with large effects.
The determined specificity conferring positions will be helpful for the mutation of one subtype into another, e.g. turning DCL to LCL, which can be a useful step for obtaining novel products.
Mutations in bacterial genomes are thought to occur at a relatively fixed rate, with a random mix of helpful, harmful and neutral mutations.
Most people think of inbreeding as bad, but it could be helpful in purging deleterious mutations from a population".
In contrast, if mutations were helpful to protect energy reserves, they were positively selected during evolution.
Detection of mutations is helpful in clinical management of imatinib resistance.
Although GNAS, KRAS, and TP53 mutations are helpful in identifying patients with IPMN, they occur early in the development of IPMNs and cannot be used to identify those individuals with high-grade dysplasia or invasive disease.
As an organization tool, this approach is helpful in identifying somatic mutations as candidates for targeted therapy that are most likely to impact multiple cancer types, and it identifies associations of mutations that may be informative as to mechanisms of resistance to targeted therapy.
