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The observed higher incidence in our study could be attributed to the heavily administered prior therapies or the addition of everolimus.
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For a short time, before being sent to her current station at Tyson Foods, Sherry worked at a processing plant in Albertville, Alabama -- Wayne's Farms -- that did not heavily administer chemicals throughout their processing operations.
These programmes are centrally administered, heavily controlled and focus on a few specific conditions (commonly linked to current donors' priorities, e.g. Malaria) to maximize likelihood of impact [ 15].
PL-MLP has a long circulation time, was well tolerated, and can be administered to heavily pretreated patients at a single dose of 3.0 mg/kg and cumulative dose of 10 12 mg/kg before development of prolonged thrombocytopenia; this is nearly threefold the equivalent dose of MMC tolerated historically.
But it also became heavily used by doctors who administered it intravenously in outpatient clinics for periodic patient "tune-ups," as they were sometimes known.
A pilot version typically starts under favorable conditions, crafted to precise specifications and administered by people heavily invested in its success.
The challenge with most promising anti-poverty programs is finding a way to "scale up". A pilot version typically starts under favorable conditions, crafted to precise specifications and administered by people heavily invested in its success.
Patients receiving venovenous or venoarterial ECMO have traditionally been considered too unstable for active physical therapy, frequently are heavily sedated, and occasionally are administered neuromuscular blocking agents.
53, 54 In the first trial, oregovomab was administered to 13 heavily pretreated, recurrent ovarian cancer patients, including 6 women with platinum-resistant disease.
The introduction of the platinum compound oxaliplatin in the treatment of colorectal cancer has increased response rates up to 25% even in heavily pretreated relapsing patients when administered in combination with 5-FU (Bleiberg, 1996).
In conclusion, the present phase I trial showed that the combination of low-dose NGR-hTNF and standard-dose doxorubicin is feasible, safe, and well tolerated when administered to patients heavily pre-treated with chemotherapy, including anthracyclines.
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