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Given literature demonstrating that aberrant immune activation is observed in HD patient CSF even prior to onset of disease symptoms,40 our finding that patient CSF has aggregation enhancing activity may reflect multiple molecular characteristics of disease.
Previous studies have demonstrated that Aβ43 has aggregation properties similar to those of Aβ42, yet Aβ43 is significantly more neurotoxic when applied to cells in culture.
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An interesting corollary to HA aggregation caused by cations, is the clouding that occurs when the solutions are heated.
Progressive HA aggregation through the addition of a metal ion is visualized in Fig. 5. Figure 5 Visualization of HA aggregation through continued addition of a metal ion, M2+.
Aggregate Quantification The httQ74-HA aggregation was detected by immunofluorescence (primary HA antibody).
When IS is equal to or greater than the CCC, on the one hand HA promotes aggregation of TiO2 NPs, but on the other hand HA decreases the rate of Ag NP aggregation because the existence of a surface coating may limit the adsorption of HA on these Ag NPs.
Previous studies show that colloidal suspension of clay minerals and iron oxides that also contain abundant organic matter (OM), especially humic acid (HA), resists aggregation under increased electrolyte concentrations [26 31].
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