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However, with the notable exception of all-trans retinoic acid (ATRA) in a subset of AML known as acute promyelocytic leukaemia (APL [10], and imatinib mesylate (Glivec) and its derivatives in chronic myeloid leukaemia (CML [11], few of these therapies have as yet had a large scale impact.
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Studies which incorporate newer information technology may lead to more sustained changes as they are simple to administer, and can have a large scale impact by inexpensively involving a variety of health professionals and/or consumers [ 55, 56].
Such small prompts or changes in the way options are presented to people can have a large-scale impact.
"EcoBoost engines can have a large-scale impact on global carbon dioxide, fuel consumption and oil imports".
The modelling effort, along with new data pouring in from Nasa's latest CO2-monitoring satellite, will give scientists better insights into sources and sinks of CO2, but the current effort provides one of the clearest views yet of just how humans are having a large-scale impact on the atmosphere and the planet it surrounds.
Prior to 1980, the ASP started out focusing on using algae to produce hydrogen, but the DOE gradually shifted its emphasis on technologies that could have a large-scale impact on national energy consumption after 1980 and therefore prompted the ASP to focus on algae's ability to produce biodiesel.
Founded in 2012, the Tata Center's mission is to create appropriate, sustainable solutions that can have a large-scale positive impact on communities in the developing world.
If the results for one of the intervention arms (NAC plus food or cash assistance) are positive, demonstrating that PLHIV who receive the intervention are more likely to be retained in care and/or have better treatment adherence, a large-scale impact evaluation to determine cost-effectiveness and examine issues of scale and sustainability may be warranted.
That is, I might as well find people are good at getting stuff done in areas that somehow matter to me, that might have large scale impact.
The core innovations of most organizations we reviewed are in business rather than medical processes, demonstrating that it is possible to have large scale impact by implementing existing care processes using innovative marketing, finance and operating strategies.
One area in particular where innovation has the potential for large scale impact – while also delivering value to businesses and society -- is in providing refugees with high demand digital and Information and Communications Technology (ICT) skills.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com