Exact(8)
One exception was a HR tumour with MNA and 1pLOH that progressed during HR treatment and the patient eventually died.
Surprisingly, we found that Gli2P1-4 is localized to the tips of cilia in the presence of DMSO (Fig. 4C, Table 2; n = 30/30 for 4 hr treatment and 30/33 for 18 hr treatment), but not in the presence of forskolin (Fig. 4C, Table 2; n = 1/31 for 4 hr treatment and 11/68 for 18 hr treatment).
Interestingly, we found that forskolin treatment greatly diminishes the ciliary localization of Gli2 (Fig. 4A, Table 2, n = 0/60 for 4 hr treatment and 10/95 for 18 hr treatment), but only moderately reduces the ciliary localization of Gli1 (Fig. 4A, Table 2, n = 14/30 for 4 hr treatment and 26/43 for 18 hr treatment).
After 24 hr treatment with peptides, a profound increase in α7-nAChR protein levels was observed.
Similar results were obtained when sulindac was included during the 2 hr treatment with the oxidizing agent.
The Gadd45b gene was reported to be induced by a 24 hr treatment with TCPOBOP in the mouse liver [21].
Hepatocyte glucose production was estimated after a 24 hr treatment with HN, F6AHN or saline as described before [26].
Seventy-two hr treatment with high glucose caused a dramatic reduction in both Insulin 1 and Insulin 2 gene expression, an indication of glucose toxicity (Fig. 1B).
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