Sentence examples for HR proficient from inspiring English sources

The absence of NHEJ failed to enhance their hypersensitivity to IR (in both HR proficient and HR-depleted backgrounds), suggesting a non-redundant role for HR in the repair of IR-induced damage in the early embryo (Fig.  5).

None of the four PDX thought to be HR proficient showed regression or disease stabilization in response to rucaparib treatment in vivo.

This is supported by a decrease in the DRB-induced UV sensitisation in G1, observed in HR proficient cells.

As shown in the figure 6d, there was a significant reduction in the number of HR proficient LNCaP cells upon VPA treatment.

These cells were more sensitive to IGF-1R inhibition compared to HR proficient cells.

Further, we hypothesized that IGF-1R inhibition might sensitize HR proficient cancers to Poly ADP ribose polymerase (PARP) inhibitors.

Co-inhibition of ARTDs and histone deacetylases (HDAC) with Olaparib and Suberoylanilide Hydroxamic Acid (SAHA) respectively is an example where a positive synergy was demonstrated using HR-proficient ovarian cancer cell lines against which Olaparib alone has minimal efficacy as a single agent34.

BRCA1, BRCA2, or ATR expression was dose-dependently reduced using siRNAs in the MMR- and HR-proficient cell line, MCF7.

(C ) Effect of knock-down of BRCA1, BRCA2, and ATR mRNA on olaparib sensitivity of the MMR-proficient, HR-proficient MCF7 cell line.

Accordingly, HR-deficient neoplasms, such as those bearing loss-of-function mutations in the genes encoding breast cancer 1, early onset (BRCA1) or breast cancer 2, early onset (BRCA2), are generally more susceptible to the genotoxic effects of CDDP than HR-proficient cancers of the same type.

Consistently, the function of SWR1/Htz1 at DSBs is unclear, because htz1Δ, but not swr1Δ is defective in DSB processing, and swr1Δ is proficient in HR and only slightly affected in non-homologous end joining (NHEJ) [22], [31].