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QTL for milk and milk composition persistency in cattle have been reported on chromosomes 1, 2, 6, 9, 14, 15, 17, 18, 21, 22, 25 and × using a granddaughter design of German Holstein dairy cattle [ 28].
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Data obtained by genome-wide association studies can be used to deduce QTL genotypes of sires via application of the a posteriori granddaughter design for concordance testing of putative QTN.
A quantitative trait locus for fertility near the centromere was confirmed by application of the modified granddaughter design to a single family.
A statistical model was applied to a granddaughter design to analyze 16 German Holstein families.
An approach somewhat similar to the granddaughter design for detecting quantitative trait loci in dairy cattle was followed.
A granddaughter design consisting of 18 elite sire families and a total of 713 sons was genotyped for 154 markers spanning the QTL region, and the trait data were analyzed by using a combined linkage and linkage disequilibrium approach.
For the chromosome wide QTL scan, animals were organized in a granddaughter design consisting of 18 elite sire families with a total of 716 sons and 507,000 granddaughters.
A granddaughter design consisting of 31 (BTand and 30 families (BTA10) with a total of 1432 (BTand and 1419 (BTA10) sons was used for confirmation studies.
A granddaughter design consisting of 6 German Holstein grandsire families with 1,054 progeny-tested genotyped sons was used in this study.
The analysis of a granddaughter design involving 833 sons of 20 grandsires resulted in 59 MQR (α = 0.01, chromosomewise).
The analysis included 12 half-sib families containing a total of 494 bulls in a granddaughter design.
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