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Our results indicate a gradually evolutionary process to extend the functional diversity of duplicate genes by evolving novel epistatic interactions after gene duplication, providing an important picture for how epistasis evolves in nature.
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Although studies of cancer have gradually incorporated evolutionary perspectives (see Aktipis et al. 2011), evolutionary explanations are often inserted into discussions of cancer rather than being used as a conceptual framework.
Vertebrate coexpression clusters are thought to arise gradually over evolutionary time, and some are conserved between human and chicken [ 26], and human and mouse [ 27].
As a result, the choosiness of females gradually declined over evolutionary time.
It is a trait that is gradually losing its evolutionary rationale.
The commonly told story is familiar and has not changed much since Darwin first proposed it: A light-sensitive nerve gradually changes over evolutionary time, adding complexity across the generations.
This pattern is paralleled by recent studies that showed gradual acquisition of characters in the forelimb of this lineage [10], suggesting that many of the numerous features that previously distinguished Sauropoda from other dinosaurs appeared gradually in the evolutionary history of Sauropodomorpha.
The size of the functional and non-redundant fraction of genomes gradually increased in evolutionary time (Fig. 1).
Dicots, monocots and non-flowering land plants form three distinct groupings, with low E values that gradually increase with evolutionary distance from the reference species.
First, the natural drift of sequence changes in a gene or protein occurs gradually on an evolutionary time-scale (Creighton, 1993).
Classical population genetic theories suggest that duplicated genes have identical sequences immediately following duplication, and then gradually diverge over evolutionary time [ 1].
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