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Given its role, it is not surprising, but yet striking, that the spindle assembly checkpoint can delay anaphase in response to a single uncaptured chromosome, exhibiting excellent sensitivity.
Given its role in modulating cell proliferation, it is not surprising that p16 alterations are one of the most common genetic/epigenetic alterations in cancer.
Given its role in Bub1 kinetochore recruitment, it is not surprising that Mps1 inhibition delays the centromeric accumulation of the CPC.
Given its role in KRAS wild-type colorectal cancers, it has also been studied in the first-line setting in advanced BTC phase II trials.
Given its role as a master regulator of redox metabolism, it is perhaps not surprising that Nrf2 may affect the activity of this organelle.
Given its role in converting testosterone to dihydrotestosterone and cortisol to dihydrocortisol, 5α-reductase may be important in the pathophysiology of the polycystic ovary syndrome (PCOS).
Given its role in autoimmune disorders, therapeutic approaches based on its blockage has been proposed.
Given its role as a grassroots social movement organization and not a professional association (which can be more closely aligned with governments), we hypothesized that the CCAAC would take a conflictual approach to the federal government's policy initiative.
Given its role in splicing, PRPF3 is assumed to be ubiquitously expressed.
Given its role in these important diseases we sought to determine how cadherin-11 expression is regulated.
Given its role in diverse stress response, we postulated that this chaperone might also regulate crucial responses to iron deprivation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com