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However, you can't tell for an individual patient whether it's placebo effect or a genuine effect.
It is often repeated that a low P-value provides more persuasive evidence for a genuine effect if the power of the test is high.
Moreover, obesity may wax and wane with or without treatment, and thus a longer follow-up period with serial measurements of outcomes is suggested to determine the genuine effect of acupuncture as well as its long-term efficacy.
Variability of weight gain after surgery was somewhat higher in the hM4Di group, but this effect was not observed in either the lesioned animals (Figure 1c) or a subsequent group of hM4Di mice (Supplementary Figure 4), suggesting that this was due to random fluctuation and does not reflect a genuine effect.
Besides, the variant effectiveness of policy schemes due to different policy timings admonishes the policy makers to realize that the current fragmented regime of policy making between different departments is undesirable for capturing the genuine effect of all of the policies.
Further analyses suggest that the origin of this latter effect is not underpinned by technical aspects of source reconstruction, but rather by a genuine effect of brain state; short recordings are simply inefficient at capturing the canonical MEG network in a single subject.
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Testing the genuine effects on cognition of the anti-epileptic drugs is methodologically not easy.
Sample preparation is included in the analysis and genuine effects of processing are investigated.
He wants to open data to the world and analyze all the data sets in the same way to see if "any signals survive". Hu is more cautious (partly to safeguard confidentiality) but does believe wider access to data and checking results against multiple data sets will help identify genuine effects.
With almost half of improvements even in the treatment group being attributable to placebo, studies require larger populations for any genuine effects of treatment to be clear.
Although, in this instance, the most likely explanation for the differences between quintiles in the apparent effect of treatment is unmeasured confounding, the possibility of a genuine effect-measure modification should be considered.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com