Diets were fed to allow for 800 g/d of body weight gain and fed 1×/d.
Consistent with the reduced body mass gain, scallop-fed mice had reduced visceral and subcutaneous fat depots; MeWAT (P < 0.001), eWAT (P < 0.001), p/rWAT (P < 0.001), iWAT (P < 0.001) and iBAT (P = 0.001) compared to chicken, cod and crab-fed mice (Fig. 2a).
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Conclusions: Feeding DHA+ARA from single-cell triglycerides enhances weight gain in formula-fed premature infants with no evidence of adverse effects.
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Diet had the largest impact on weight gain and lard-fed GF mice gained significantly more weight than fish-oil fed Gfish-oil fed
36, 43, 44 Chronic treatment with the PDE5 inhibitor sildenafil has been reported to reduce weight gain in HFD-fed mice.
Mean daily weight gain among formula-fed infants during the first 4 months of the study was between 30 32 g/day (Table 2).
Importantly, except slightly decreased liver mass in scallop-fed mice no differences were seen in lean body mass between groups, effectively ruling out impaired protein synthesis as the explanation of the reduced body mass gain in scallop-fed mice.
We observed a higher body weight gain in HFD-fed TP53INP1 KO than WT mice (Fig 1A and Supplementary Fig S2A), although food consumption did not differ between genotypes (Supplementary Fig S3).
