In addition, culture, and thus confirmation, of DR TB in HIV-infected patients with smear-negative pulmonary TB and extra-pulmonary TB is difficult in many clinical settings, leading to further under-estimates.
The Bonferroni adjustment for multiple test is a conservative methodology and could have further under-estimated the level of significance in some cases [ 23].
Further, we estimated frequency shifts (FSs) of individual segregating loci and gametic linkage disequilibria (LDs) between segregating loci resulting from step-wise directional selection towards either increased or decreased trait values under each scenario using the Bennett's method [35].
In this setting, the use of case-fatality rate estimates in prediction models may grossly under-estimate the survival benefit of further improvements in utilization.
DCIS was under estimated in 40%.
They under-estimated her.
And often, she under-estimated herself.
Here, Fonda under- estimates the trouble with boys.
You can't under-estimate how hard it is.
"People under-estimate the importance of handwashing.
We may under-estimate under notification of these patients.
