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Six further trialists agreed to be interviewed and provided a copy of their protocol, but did not respond to any further email contact.
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Reviews were checked to see whether review authors had contacted trialists for further information or data for outcomes.
Considered alongside a study examining willingness to participate in hypothetical asthma trials which suggested that adolescents were significantly more willing than parents to enrol in above-minimal risk research [ 99], this raises further complexities for paediatric trialists.
In order to interview a similar number of trial investigators from the other two groups that is, trials from the same Cochrane reviews that were considered to show no outcome reporting bias and the randomly selected cohort of PubMed trials a further 98 and 85 trialists, respectively, were approached.
Meanwhile, McCoist hopes to assess trialist Joe Sise further next week.
The contrast between parents' and clinicians' and trialists' views warrants further investigation but it is unlikely that parents always approach decisions about trials in the way imagined by some – a rational and mechanistic process of weighing up all of the available information before reaching a decision [ 45, 49].
A recent joint statement of trialists and scientific associations further supports this point of view (12).
In this article, we focus on the potential explanations for trialists' decision to initiate further trials of TXA, yet there is also a question regarding why patients continue to agree to participate in apparently 'redundant' trials in which there is a chance they will forego receiving an effective treatment.
The remaining trialists and trialists of any further trials identified as eligible will be approached at the start of the project and we anticipate their willingness to collaborate.
The third and fourth intentions set out by the CEA trialists were (C) to obtain further data relating CEA levels to tumour histology and topography and (D) a large database on the natural history of colorectal cancer.
The development of such a resource would require considerable investment, but the support for the basic concept that is evident among trial participants, consumer advocates and trialists suggest that it warrants further investigation and evaluation.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com