The current controversy surrounding this catalytic system is focused on the role of the M2 phase, which is unable to activate propane but was suggested in some studies to function in synergy with the M1 phase by efficiently converting the propylene intermediate to ACN.
Airway clearance therapies are likely to function in synergy with antimicrobial therapy to accelerate resolution of airway infections.
It is possible that VSL#3 may function in synergy with, or perhaps increases, the anti-inflammatory action of 5-ASA compounds.
Recently, RICTOR, the unique structure of mTORC2, was found to be necessary to the tumor formation of PTEN-deficient prostate epithelial cells in nude mice, indicating that mTORC2 can function in synergy with PI3K to promote tumorigenesis [ 50].
In one of the recent publications, HoxC4 was implemented into the AID promoter regulation via binding to a highly conserved HoxC4-Oct site; this site functions in synergy with a conserved binding site for the transcription factors Sp1, Sp3, and NF-κB [ 16].
SULTR3 5 functions in synergy with SULTR2 1 in mediating low-affinity sulfate transport when expressed in yeast and participates in root-to-shoot sulfate transport [ 14].
This regulatory mechanism has been proposed to function in synergy with resynthesised IκBα to efficiently terminate NF-κB responses (Saccani et al, 2004).
Is IL-18 therefore a good therapeutic target in RA? IL-18 functions in synergy with numerous cytokines present within the synovial compartment including IL-12 and IL-15 and as such it probably serves to amplify ongoing inflammatory responses ('adjuvant-like').
TG-repeats determine CFTR protein function and work in synergy with poly-T [ 24].
In fact, genes are not functionally independent; they work in synergy to perform certain biological functions, such as biological processes, molecular function, complexes or pathways [ 20- 22].
