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Yet, for such columns to be functionally operative, adequate isolation from neighboring units would be required.
Early human brain development constitutes a sequence of intricate processes resulting in the ontogeny of functionally operative neural circuits.
Our findings provide novel evidence that the JNK signaling pathway is functionally operative in the malignant transformation of osteoblasts and the subsequent development and progression of human osteosarcomas.
The present results show that the sweet taste receptor is expressed in β-cells and is functionally operative.
It has been known that both holo TFIIH and core TFIIH are functionally operative in reconstituted dual incision systems, whereas CAK appeared to negatively regulate the in vitro dual incision [5].
Furthermore, old sequences that once had a function in the immune response can be reactivated by recombination, positioning them in the correct context of functionally operative promotors and/or enhancer elements.
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We therefore believe that there is no indication to treat a proven scaphoid fracture functionally without cast immobilisation or operative fixation.
These procedures, although often functionally and aesthetically successful, are often staged, and they therefore introduce operative risks, significant investments of surgeon and patient time, and extraordinary costs.
It is expected that patients under the post-operative TUG cut-off would tend to be functionally independent at home, while patients above the cut-off would need additional resources, either through inpatient rehabilitation, or at home.
In contrast, the trans-acting pathway identified in this study, which can be functionally defined by its sensitivity to the intracellular concentration of σ, is potentially operative on all transcription units.
In a larger sense, they also suggest that functionally relevant epigenetic and transcriptional alterations mobilized by Atrx deficiency in murine mNPCs are also operative in ATRX-mutant human gliomas.
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