Frontline treatment of CML involves the use of Imatinib (Glivec®) (Appendix 1, Note 1).
Frontline treatment for nonresistant strains includes 6 months of therapy with a combination of four drugs: rifampin, isoniazid, ethambutol, and pyrazinamide.
Hallek M. Signaling the end of chronic lymphocytic leukemia?: new frontline treatment strategies.
Randomized trials demonstrated the superiority of chemoimmunotherapy over chemotherapy in the frontline treatment of CLL.
Antiepileptic medications are the frontline treatment for seizure conditions but are not without cognitive side effects.
Initially used in the relapse setting, these agents have been incorporated into frontline treatment algorithms.
Meanwhile, American physicians were diagnosing hyperactivity in children in the late 1960's, and regarded stimulants as standard frontline treatment.
Jakubowiak, A. J. et al. A phase 1/2 study of carfilzomib in combination with lenalidomide and low-dose dexamethasone as a frontline treatment for multiple myeloma.
In the former, new drugs with improved efficacy and reduced toxicity entered the clinic; in the latter, immune-checkpoint inhibition proved efficacious after chemoradiotherapy for stage III disease, but had disparate results in the frontline treatment of stage IV disease.
Even though HDT/ASCT is the standard frontline treatment for newly diagnosed multiple myeloma patients, ASCT is not curative, and progressions and relapses are common even if CR is attained post-transplant6,7,82 post-transplant6,7,82
Despite the wide usage, mild side effect profile, and commendable efficacy of rituximab in frontline treatment of indolent lymphoma, resistance to this agent commonly develops, ultimately limiting patient treatment options.
