Bortezomib in the front-line treatment of multiple myeloma.
Given the potential survival benefits, front-line treatment of AYA ALL at pediatric and/or NCI/COG-designated cancer centers should be considered.
Lenalidomide was subsequently investigated as front-line treatment of DLBCL in combination with standard R-CHOP chemoimmunotherapy administered every 21 days (R2-CHOP21).
The purpose of this study was to evaluate the efficacy of erlotinib as front-line treatment in clinically selected patients with non small-cell lunon small-celllung
Also, these drugs are being increasingly used in the peri-transplant setting for transplant-eligible patients, and as part of consolidation and/or maintenance after front-line treatment, including in transplant-ineligible patients.
Review of the literature for paclitaxel based front-line treatment combined with EP therapy, in extensive stage SCLC, consistently shows a CR rate <20% but high overall response rate is maintained (thus most responses are partial).
The purpose of this study is to assess the safety profile of brentuximab vedotin sequentially and in combination with multi-agent chemotherapy in front-line treatment for CD30-positive mature T-cell and NK-cell neoplasms, including systemic anaplastic large cell lymphoma.
In multivariable analyses, front-line treatment in a pediatric (vs adult) setting (OS HR = 0.53, 95% confidence interval [CI], 0.37-0.76; LSS HR = 0.51, 95% CI, 0.35-0.74) atd an aNCI/Childrenen's Oncology Group COGG) center (OS HR = 0.80, 95% CI, 0.66-0.96; LSS HR = 0.80, 95% CI, 0.65-0.97) were associated with significantly superior survival.
Dr Vasan worked as a Technical Officer on the WHO/UNAIDS "3by5 Initiative" to expand antiretroviral treatment access in the developing world, and subsequently supported the Ugandan Ministry of Health in scale-up and quality improvement of HIV treatment in four districts in the southwest of the country, the first areas to attempt front-line treatment.
Suffolk's drug action team says front-line treatment will not be affected by proposals to cut the county council's budget by £42.5m.
Prof Nosten says the current spread of resistance could be similar to what happened in the 1970s with chloroquine, a drug that was once a front-line treatment against the disease.
