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Free iron in tissues may start Fenton like reaction resulted in a hydroxyl free radicals generation [42].

Free iron, copper, and zinc can be measured.

Free iron ions are able to initiate cellular damage [ 46].

Free iron is required for growth (e.g. ferroprotein synthesis) but also generates oxidative stress.

Free iron is associated with cancer development through the induction of persistent oxidative stress.

Free iron can increase oxidative stress, thereby acting as proinflammatory agent (14).

Free iron has been shown to potentiate bacterial growth in vitro.

Free iron is also known to catalyze the formation of highly reactive oxygen species [ 13, 14].

Free iron is rapidly sequestered into the iron-storage protein ferritin, leading to additional antioxidant and antiapoptotic effects [ 6].

Free iron is a pro-oxidant and can catalyse lipid peroxidation and DNA damage (McCord, 1998; Huang, 2003).

But often the host organism does not have much free iron around.

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