Hsu et al. [ 32] proposed a parameter-free interconnectedness method to rank disease candidates by evaluating their distance to known disease genes in a network.
We compare our approach with a state-of-art parameter-based approach (PageRank with Priors or PRP) and with another parameter-free method (Interconnectedness or ICN).
We developed a parameter-free method, interconnectedness (ICN), to rank candidate genes by assessing the closeness of them to known disease genes in a network.
With volatility spiking and a renewed sense of crisis upon us, economic interconnectedness and free capital flows unite the world in an interlocking web of vulnerability.
For larger, more complex species, the interconnectedness of high free volume domains plays a role in reducing the apparent diffusion constant as the time of measurement increases.
The parameter-free methods (e.g. Interconnectedness or ICN [ 29]), on the other hand, measure closeness of each candidate gene to known disease genes by taking into account direct link and the shared neighbors between two genes and tend to be less intensive computationally.
It has also come to be used by right-wing media and figureheads as a pejorative way to describe people of a certain political ideology: those who believe in the benefits of globalization and generally support greater interconnectedness between countries and free-market trade policies.
WE THE PEOPLE of the free and independent United States hereby declare our interconnectedness and responsibility for one another.
To compare the performance of our VS-based approach in candidate disease gene ranking, we select two methods, one each from parameter-based and parameter-free methods: PageRank with priors (PRP) [ 28] and Interconnectedness (ICN) [ 29].
And for this we can thank the powerful forces unleashed by free trade, the wider adoption of market capitalism, and the growing competition and interconnectedness of the world's economies.
The principle of free speech on which the United States was founded was not conceived with our modern interconnectedness in mind, nor has it scaled to adapt to it.
