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For some disorders, such as depression, we may never know, in any useful way, what the underlying pathology is, since we can't distinguish biologically patients who are suffering from depression from patients who are enduring a depressing life problem.
For some disorders, such as familial hypertrophic cardiomyopathy, long QT syndrome, and familial hypercholesterolaemia, genetic testing has a high yield and has become an integral part of family management.
For some disorders, a rare variant can be associated with a relative risk of greater than 1,000.
For some disorders, however, other symptoms like liver damage are also a consistent clinical finding (Platt et al., 2012).
For some disorders, food products restricted in the offending material are available without modification of conventional products, e.g., galactosemia is treated in infancy by conventional formulas using sucrose as a sugar source rather than the galactose-containing disaccharide, lactose.
Indeed, for some disorders the new mutation rate is quite high; almost 7 out of 8 children with achondroplasia are born to two unaffected parents.
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I think the founder effect is true for only some disorders, but not for all of them, and there must be something else.
[My sergeant] said in the van basically en route that there was potential for some disorder.
Exclusive induced fit mechanisms have been proposed for some disorder-to-order transitions, whereas mixed mechanisms have been suggested for others.
Preterm survivors from the neonatal intensive care unit (NICU) are considered to be at risk for some neurobehavioral disorders such as attention-deficit/hyperactivity disorder (ADHD).
Further, the present study evaluated specific symptom clusters for different types of mood and anxiety symptoms whereas Zinbarg et al. collapsed outcomes into depressive and/or anxiety disorders because of limited sample sizes for some individual disorders.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com