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For simulations, we used Monte Carlo simulators.
For simulations, we set M t = 2.
For simulations, we use up to Rh=4.
For simulations of unperturbed neurons 45 µM of mobile calbindin-D28k was included [8].
For simulations with all three chains restrained, the spring constant was reduced by 1/3.
For simulations of a cluster as suggested by Crawford et al.
For simulations the systems were initially processed in the CHARMM-GUI web server [ 27].
For simulations of mutation accumulation, gonadal arms are seeded with a single progenitor cell.
For simulations, we used Berkeley Madonna (version 8.3.18, University of California at Berkeley, CA).
For simulations of metaparticle formation, we set w = 0.035σ, αrep = 0.2σ, and αatt = 0.01σ.
A NS-2 simulator is used for simulations.
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