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In 2013, Monsanto requested and received approval from the US Environmental Protection Agency for increased tolerance levels for glyphosate.
Boyarskiy, S., Davis López, S., Kong, N. & Tullman-Ercek, D. Transcriptional feedback regulation of efflux protein expression for increased tolerance to and production of n-butanol.
These results indicate the feasibility of engineering tomato for increased tolerance of abiotic stress, without decreasing productivity, under both stress and nonstress conditions through trehalose biosynthesis.
Chemical mutagenesis selecting for increased tolerance may lead to down-regulation of the genes responsible for the desired products ([Borden and Papoutsakis 2007]).
In addition to attenuating the inflammatory response, the analgesic effect of NSAIDs may assist in pain management in the recovering athlete, allowing for increased tolerance of rehabilitation exercises [15].
Mechanisms for increased tolerance may include mutations in apoptotic pathways (such as caspase or p53) or upregulation of NHE-1.
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Reverse engineering has provided rational design strategies for increasing tolerance to isobutanol, furfural, and ethanol as well as increasing the production of succinate.
Identification of the mutations that enable the evolved phenotype and understanding the molecular basis of their contribution to strain fitness and performance can reveal novel strategies for increasing tolerance.
Pre- and post-survey results showed majorities of respondents held negative attitudes toward wolves with no decrease in inclination to poach, suggesting lethal-control measures, in the short term, may be ineffective for increasing tolerance.
Random mutagenesis is a generally an accepted and widely used approach for increasing tolerance of a bacterial strain towards an unknown inhibitor.
Therefore, the mutant sor1 gene and other genes for soil-surface rooting may be useful for increasing the efficiency of absorption of nutrients accumulated at the soil surface in untilled culture systems and for increasing tolerance to some of the problematic soil types.
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