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For better elucidating the quantitative structure activity relationship of NF-κB inhibitors and determining possible ligand protein interaction, a pharmacophore model, Hypo1, was built based on 35 training molecules by Catalyst/HypoGen algorithm.
In addition, SIRT1 mutations within the NLS and/or NES domain(s) would be useful tools for better elucidating the specific functions of nuclear and cytoplasmic SIRT1.
One promising approach for better elucidating the common mutational patterns by which tumors develop is to recognize that tumor development is an evolutionary process and apply phylogenetic methods to tumor data to reveal these evolutionary relationships.
A promise for better elucidating the genetics of lithium response has been created by the formation of the Consortium on Lithium Genetics (ConLiGen) to establish the largest sample, to date, for the GWAS of lithium response in bipolar disorder.
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Future studies will need to account for these factors to better elucidate HRV effects.
A more consistent and comprehensive method for FC quantification may better elucidate the unknown factors associated with plaque rupture.
On page 4, the authors state their motivation for the study as "To better elucidate the transcriptional mechanisms underlying Th cell identity…".
The latter may have permitted volume-efficiency relationships to be better elucidated, and for the specific number of cases required to reach maturation to be determined.
However, the potential positive influences a KD may have on cancer treatment justify the need for well-designed clinical trials to better elucidate the mechanisms by which this dietary approach affects nutritional status, cancer prognosis, and overall health.
Though most studies have used PM mass concentration as the exposure metric, an alternative which accounts for particle toxicity due to varying particle composition may better elucidate whether PM from specific sources is responsible for observed health effects.
Understanding the relationships between ORA measures and ocular dimensions may help better elucidate the significance of, and applications for, the metrics it produces.
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