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While genes have been identified that can mark individuals at risk for substance abuse, the initiation step of addiction is attributed to persistent metabolic disruptions occurring following the first instance of narcotic drug use.
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This was reported to be the first instance of 'artificial life,' and in the ethical and policy discussions that followed it was widely assumed that the creation of artificial life is in itself morally significant.
The aim with the new funding is to get a first product into the local market by spring 2018 (and thereafter other markets in Europe, followed by North America) — in the first instance as a home care product for babies up to three months old and/or to help parents that are transitioning a premature baby from a hospital incubator to a crib at home.
Although the Committee on Economic and Monetary Affairs has, at my proposal, followed this suggestion in the first instance, I do think that we should review the practical implications in a few years' time, because we have no idea of how many businesses, how much state aid in total, and how many applications for state aid are involved.
The committee called for all complaints to be made to the BBC in the first instance, followed by a right of appeal to the BBC Trust and a subsequent final appeal to Ofcom if the complainant was not happy with the trust's decision.
In case of MePEG80-PCL20 MePEG60-PCL40CL40 micellar formulation, pyrene release was found to be 61 ± 1.3 % and 59 ± 1.6 %, respectively, in the first instance, followed by slow and continuous release.
In this case, the LCOE calculation procedure is reversed: the LCOE target is set in the first instance, followed by the calculation of the Average Energy Production AEPP) based on different scenarios.
"Defendants provide no basis to deviate from the well-established and well-justified procedures that have generally been applied in federal courts for generations — whereby district courts decide cases in the first instance, followed by an appeal by the losing party, on a full record, to the court of appeals and, thereafter, a petition to the Supreme Court," Judge Furman wrote.
Similarly, in case of MePEG40-PCL60 MePEG20-PCL80CL80 micellar formulations, the release was 56 ± 1.4 and 51 ± 1.2 %, respectively, in the first instance followed by sustained release (Ma et al. 2008).
In contrast, in our study, our assumption (based on advice from clinical colleagues) was that all women who experienced failure with the Mirena strategy would, in the first instance, follow the second generation endometrial ablation pathway.
Recruited patients undergo telephone screening in the first instance, followed by a pre-trial assessment by a research nurse, to confirm eligibility and collect baseline information.
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