The observed transcriptional response, as well as its functional outcome, followed a temporal sequence, with regulation of gene expression and signal transduction leading to changes in metabolism and cell proliferation.
All in all, we show that BMP4 and BMP7 have strong effects on gene expression in breast cancer cells, and that this transcriptional response and its functional outcome follow a temporal sequence.
The myosin loss and muscle wasting follows a temporal sequence with an initial sparing of both muscle function, mass and myosin content followed by a progressive loss of muscle force that exceeds the loss in muscle mass due to a preferential loss of the motor protein myosin [ 7- 9].
A reaction was classified as "definite" if (1) followed a reasonable temporal sequence after drug administration; (2) followed a known pattern of response to the drug; (3) could not be explained by concurrent disease or other drugs; and (4) was confirmed by improvement upon drug removal and by reappearance on re-challenge.
The relationship of each adverse event to the trial medication will be determined by a medically qualified clinician according to the following definitions The adverse event follows a reasonable temporal sequence from trial medication administration.
FM4-64 entheing the pollen tubes follows a strict temporal sequence from the plasma membrane to a population of small discrete internal structures, with subsequent appearance of the dye in the apical region and ultimately in vacuolar membranes [3].
There is some behavioral evidence that the occurrence of mind-wandering is not an all or nothing phenomenon but follows a gradual temporal sequence [49], [67].
Underpinning the 2011 recommendations is the recognition that the progression of AD biomarkers over time likely follows an ordered temporal sequence, and the Aβ biomarkers (e.g., low brain Aβ clearance, i.e., low cerebrospinal fluid [CSF] Aβ42; and tracer retention on amyloid positron emission tomography [PET] imaging) are representative of upstream events [ 5].
To do so, a temporal sequence and specific spatial distribution of the cells and signaling molecules involved in this particular healing process have to be followed [ 3].
Consonants in a cluster are ordered in a temporal sequence.
This implies a temporal sequence from PMv to M1.
