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Now two follow-up trials by the manufacturer have failed to confirm even those meager gains.
Pharmacokinetics of a cox inhibitor (piroxicam, 0.3 mg/kg) were studied in carcinoma-bearing cats to confirm a dose for follow-up trials.
For the limitations in this study, to drawn more solid conclusions, further large, randomized, multi-center, and long-term follow-up trials were required.
Alas, no follow-up trials pressed this point, leaving axillary dissection as a fundamental component of breast cancer treatment for 40 more years.
These results provide information (cox-2 expression as an inclusion criteria, 0.3 mg/kg daily piroxicam) for the design of follow-up trials of cox inhibitor treatment in pet cats with OSCC.
At the moment the FDA very rarely asks companies to conduct large-scale follow-up trials of new drugs after launch, and even when it does, its requests are often ignored.
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A follow-up trial added salt into the mix.
This analysis assessed the effect of raloxifene on the incidence of cardiovascular adverse events in postmenopausal women followed for ≤8 years as participants in a 4-year osteoporosis treatment trial and a subsequent 4-year follow-up trial.
A clinical trial of odanacatib, a once-weekly pill to treat osteoporosis in postmenopausal women, last July appeared to show benefits to patients, but the company continued a follow-up trial of 8,000 women to keep monitoring potential safety issues.
This month Novartis begins a follow-up trial in up to 40 Muckle-Wells patients.
[58] A follow-up trial is presently underway to evaluate the effect of paralytic agents on ARDS mortality (NCT00299650).
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