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But despite such quality control efforts, the flexibility and adaptability that aided fast replication left the National Center with no effective way to manage or monitor the more than 2,000 sites worldwide.
In Hackers and Painters: Big Ideas from the Computer Age, Graham explains how LISP made Viaweb more powerful, enabling fast replication of competitors' innovations.
The evolution of RNA viruses is governed by key features such as their fast replication, high per-base mutation rates, compacted genomes, poor robustness to mutation, stressed fitness tradeoffs, antagonistic epistasis, elevated particle counts, and strong transmission bottlenecks.
In addition, the virus has fast replication rate upon in vitro infection, where previous study on the growth of FIPV in CRFK cells showed that by 2 hours approximately 67% of FIPV 79-1146 were internalized by CRFK cells by endocytosis increasing to more than 70% at 3 hours [ 27, 28].
In all experiments, high titers and fast replication dynamics have been achieved demonstrating a chemically-defined suspension production process for influenza LAIV strains.
S. Park and J. Ousterhout, "Exploiting Commutativity For Practical Fast Replication," Proc.
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CEO of Professional Science Editing for Scientists @ prosciediting.com