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Making such a detection is extremely challenging.
Again these patients can be extremely challenging.
But doing so is extremely challenging.
Assessing such projects is, however, extremely challenging.
Oral delivery of therapeutics is extremely challenging.
However, it has proven extremely challenging.
Give Me Your Love is extremely challenging to perform.
Sequencing a highly repetitive subtelomeric region is extremely challenging.
"It was extremely challenging for the people concerned," he observes.
Getting that many resources into place quickly is extremely challenging.
Parking on the UC Berkeley Campus is extremely challenging.
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