Sentence examples for Extensive metabolism from inspiring English sources

Extensive metabolism leading to the high clearance rate of TW01003 in this study explains the unsatisfactory pharmacokinetics of TW01003.

Extensive metabolism of BaP occurred whether sole was exposed to this AH via sediment, per os, or intraperitoneally.

Here, we developed an integrated, low false positive and reaction types extensive metabolism prediction approach called RD-Metabolizer (Reaction Database-based Metabolizer).

However, the polyphenol due to its rapid and extensive metabolism exhibits low bioavailability in vivo.

Such extensive metabolism was not seen in other species (Shire-Movetis, unpublished results; partly reported in [27]).

The phenyl tropane analogs have a high or moderate affinity with other monoamine transporters (i.e., serotonin transporters [SERT] and norepinephrine transporters [NET]), or they undergo extensive metabolism.

EAR-treated Soligo roots underwent an extensive metabolism-related response (up-regulated: " raffinose synthase", " asparagine synthase", " trehalose phosphatase"; down-regulated: "nucleotide-sugar metabolism", "fatty acid desaturation").

After absorption, diltiazem undergoes extensive hepatic metabolism through three major metabolic pathways, N-demethylation, O-deacetylation, and O-demethylation [2, 3, 4, 5].

Analysis of the metabolic capabilities revealed an extensive energy metabolism with many aerobic and anaerobic respiratory options.

Differences in endoxifen concentrations between morning and evening administration seemed to be greater in women having extensive CYP2D6 metabolism compared with women having decreased CYP2D6 metabolism.

A trend towards greater differences in endoxifen exposure between morning and evening administration in women with extensive CYP2D6 metabolism, according to genotype, was observed, which might suggest a possible influence of circadian variation in (CYP2D6) metabolism.