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Several mechanisms by which oncogenes induce replication stress were recently identified, including insufficient nucleotide pools to support the extensive enforced DNA replication (Bester et al, 2011; Mannava et al, 2013), interference with the pre-replication complex assembly (Ekholm-Reed et al, 2004) and the collision between replication and transcription (Jones et al, 2013).
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It is well documented that in animals and humans intensified sensory stimulation, as enforced through extensive use or training, modifies cortical processing and cortical representations of the respective body parts [34], [35], [36], [37].
Not only because of the complexity of the existing code base, but also because coding standards are enforced, and extensive tests and documentation are required.
Not only must he oversee the monetary relief programs in the settlement, he must also enforce extensive changes to loan-servicing practices that the deal entails.
The new corporation was given extensive powers to enforce and make laws to regulate trade and ensure the good governance of the town.
She said local governments should not be required to follow corporate America's extensive disclosure rules, which are enforced by the S.E.C.
These findings were among many others that led to a consent decree, an agreement for an extensive overhaul of the jail enforced by a federal judge.
Cavalli and Mistelli postulated an extensive self-enforcing feedback between genome activity and spatial organization, and suggest a self-organizing and self-perpetuating system of the nucleus [93].
Cab signaling A more significant difference is the extensive use of cab signaling and enforced signal systems, such as ETMS and ATS in Europe.
Extensive pre-showering is mandatory and strictly enforced, as is nudity while in the bath.
It will have broad discretion to set ethics rules, such as conflict-of-interest standards for accountants auditing public companies, and assign extensive disciplinary powers to enforce them.
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CEO of Professional Science Editing for Scientists @ prosciediting.com