Hence, extensive fractionation is indispensable to reduce the dynamic range and enhance the coverage of the plasma proteome.
According to Gagne (1999), experts in music are likely to benefit more from deliberate practice than average musicians do, but extensive practice remains indispensable.
To penetrate into the deeper, private movements of Klee's thought and imagery, some consultation of his own catalogue, and the recent, still more extensive, catalogue raisonné, is indispensable.
In order to optimize accuracy of the planned corrective osteotomy, extensive preoperative planning is indispensable.
Moreover, our results showed the existence of several cryptic species, and thus more extensive morphological investigation is indispensable.
An extensive phylogenetic analysis is indispensable for the understanding of gene family evolution.
Extensive evidence has indicated that COUP-TFII plays a critical and indispensable role in cell-fate specification, organogenesis, angiogenesis, and metabolism as well as in a variety of diseases.
Recent data from a randomized trial are encouraging in terms of effectiveness and toxicity, even though a more extensive follow-up program would be indispensable.
The DDMoRe consortium acknowledges that an extensive education and training program is indispensable for delivering innovation and subsequent dissemination and management of knowledge as implemented in the context of DDM&S.
Experience with the various techniques is indispensable, as a well-performed extensive approach is associated with less morbidity than a fracture or trajectory error.
This argument seems to carry weight, and it will be fascinating to see whether the FDA responds to voices such as Orloff's argument that extensive CV safety studies must not become indispensable in diabetes drug development.
