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Hypotheses to explain the altering prognosis by the month of diagnosis include seasonal hormonal changes and social factors.
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Internal organs are potentially also subjected to the same counteracting forces, resulting in altered timing of growth spurts, which could explain the altered KD brain and heart percentage volume at E13.5 and E17.5.
Our findings explain the altered PAM specificities of the SpCas9 variants and establish a framework for further rational engineering of CRISPR-Cas9.
These alterations suggest that the cytoskeleton structures in general may be deregulated in the absence of mATX3, which may explain the altered morphologic features of mATX3-depleted cells.
Based on these early studies, we speculated that DR6 6B) might in part explain the altered p53 regulation in HHV-6B-infected cells.
Risk taking behaviour and cognitive deficits are more common among smokers, which may partly explain the altered risk for MSDs in adjusted models [ 1, 52].
A critical site for lesion-induced hyperphagia and obesity in rats is also the MePD (36), which may explain the altered pubertal timing by way of an earlier attainment of critical body mass (37).
Finally, it must be remembered that the interpretation of the changes in cleavage patterns is rather subjective and is guided by the principle that the change in a cleavage pattern is ascribed due to the simplest (smallest) conformational change which can explain the altered cleavage.
Follow up studies demonstrated that changes in copy number of Stat5ab explained the altered immune and metabolic function.
To study the effects of perturbation on a structural level, we performed a MD simulation to examine the impact of phosphorylation on the PPAR γ RXR α dimer, demonstrating that phosphorylated PPAR γ destabilizes the PPAR γ RXR α dimer, which may be a mechanism explaining the altered transcriptional regulation of PPAR γ target genes.
The divergence is most likely explained by the altered microenvironment in the nasal cavity as the CFTR mutations leads to a modified mucus composition and structure as well as defective immune response.
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